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Infect. Immun., Feb 1995, 736-740, Vol 63, No. 2
Copyright © 1995, American Society for Microbiology

Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis

J Chan, K Tanaka, D Carroll, J Flynn and BR Bloom
Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York.

We have recently demonstrated that the macrophage L-arginine-dependent cytotoxic pathway effectively kills the virulent Erdman strain of Mycobacterium tuberculosis in vitro via the generation of toxic reactive nitrogen intermediates by the enzyme nitric oxide synthase. This report demonstrates that two distinct inhibitors of nitric oxide synthase (aminoguanidine and NG-monomethyl-L-arginine) render similar deleterious effects on tuberculous infection in mice, as assessed by mortality, bacterial burden, and pathological tissue damage, thus confirming the importance of reactive nitrogen intermediates in resistance against M. tuberculosis.


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