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Infect. Immun., Sep 1995, 3609-3620, Vol 63, No. 9
Copyright © 1995, American Society for Microbiology

Association of Legionella pneumophila with the macrophage endoplasmic reticulum

MS Swanson and RR Isberg
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Legionella pneumophila replicates within a membrane-bounded compartment that is studded with ribosomes. In this study we investigated whether these ribosomes originate from the cytoplasmic pool or are associated with host endoplasmic reticulum (ER). Immunofluorescence and electron microscopic localization studies of ER proteins in macrophages infected with L. pneumophila indicated that the bacteria reside in a compartment surrounded by ER. An L. pneumophila mutant that grows slowly in macrophages was slow to associate with host ER, providing genetic evidence in support of the hypothesis that this specialized vacuole is required for intracellular bacterial growth. Ultrastructural studies, in which the ER luminal protein BiP was labeled by immunoperoxidase cytochemistry, revealed that L. pneumophila replication vacuoles resemble nascent autophagosomes. Furthermore, short-term amino acid starvation of macrophages, which stimulated host autophagosomes. Furthermore, short-term amino acid starvation of macrophages, which stimulated host autophagy, increased association of the bacteria with the ER and enhanced bacterial growth. These results are compatible with the hypothesis that L. pneumophila exploits the autophagy machinery of macrophages to establish an intracellular niche favorable for replication.


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  • Faulkner, G., Garduno, R. A. (2002). Ultrastructural Analysis of Differentiation in Legionella pneumophila. J. Bacteriol. 184: 7025-7041 [Abstract] [Full Text]  
  • Roy, C. R., Tilney, L. G. (2002). The road less traveled: transport of Legionella to the endoplasmic reticulum. JCB 158: 415-419 [Abstract] [Full Text]  
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  • Fields, B. S., Benson, R. F., Besser, R. E. (2002). Legionella and Legionnaires' Disease: 25 Years of Investigation. Clin. Microbiol. Rev. 15: 506-526 [Abstract] [Full Text]  
  • Rankin, S., Li, Z., Isberg, R. R. (2002). Macrophage-Induced Genes of Legionella pneumophila: Protection from Reactive Intermediates and Solute Imbalance during Intracellular Growth. Infect. Immun. 70: 3637-3648 [Abstract] [Full Text]  
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  • Khelef, N., Shuman, H. A., Maxfield, F. R. (2001). Phagocytosis of Wild-Type Legionella pneumophila Occurs through a Wortmannin-Insensitive Pathway. Infect. Immun. 69: 5157-5161 [Abstract] [Full Text]  
  • Sinai, A. P., Joiner, K. A. (2001). The Toxoplasma gondii protein ROP2 mediates host organelle association with the parasitophorous vacuole membrane. JCB 154: 95-108 [Abstract] [Full Text]  
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  • Sturgill-Koszycki, S., Swanson, M. S. (2000). Legionella pneumophila Replication Vacuoles Mature into Acidic, Endocytic Organelles. JEM 192: 1261-1272 [Abstract] [Full Text]  
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  • Suhy, D. A., Giddings, T. H. Jr., Kirkegaard, K. (2000). Remodeling the Endoplasmic Reticulum by Poliovirus Infection and by Individual Viral Proteins: an Autophagy-Like Origin for Virus-Induced Vesicles. J. Virol. 74: 8953-8965 [Abstract] [Full Text]  
  • Clemens, D. L., Lee, B.-Y., Horwitz, M. A. (2000). Mycobacterium tuberculosis and Legionella pneumophila Phagosomes Exhibit Arrested Maturation despite Acquisition of Rab7. Infect. Immun. 68: 5154-5166 [Abstract] [Full Text]  
  • Solomon, J. M., Rupper, A., Cardelli, J. A., Isberg, R. R. (2000). Intracellular Growth of Legionella pneumophila in Dictyostelium discoideum, a System for Genetic Analysis of Host-Pathogen Interactions. Infect. Immun. 68: 2939-2947 [Abstract] [Full Text]  
  • Coelho, A., Andrade, J. R. C., Vicente, A. C. P., Dirita, V. J. (2000). Cytotoxic Cell Vacuolating Activity from Vibrio cholerae Hemolysin. Infect. Immun. 68: 1700-1705 [Abstract] [Full Text]  
  • Harb, O. S., Abu Kwaik, Y. (2000). Characterization of a Macrophage-Specific Infectivity Locus (milA) of Legionella pneumophila. Infect. Immun. 68: 368-376 [Abstract] [Full Text]  
  • Hales, L. M., Shuman, H. A. (1999). The Legionella pneumophila rpoS Gene Is Required for Growth within Acanthamoeba castellanii. J. Bacteriol. 181: 4879-4889 [Abstract] [Full Text]  
  • Coburn, J., Frank, D. W. (1999). Macrophages and Epithelial Cells Respond Differently to the Pseudomonas aeruginosa Type III Secretion System. Infect. Immun. 67: 3151-3154 [Abstract] [Full Text]  
  • Segal, G., Shuman, H. A. (1999). Legionella pneumophila Utilizes the Same Genes To Multiply within Acanthamoeba castellanii and Human Macrophages. Infect. Immun. 67: 2117-2124 [Abstract] [Full Text]  
  • Way, S. S., Sallustio, S., Magliozzo, R. S., Goldberg, M. B. (1999). Impact of either Elevated or Decreased Levels of Cytochrome bd Expression on Shigella flexneri Virulence. J. Bacteriol. 181: 1229-1237 [Abstract] [Full Text]  
  • Pizarro-Cerda, J., Meresse, S., Parton, R. G., van der Goot, G., Sola-Landa, A., Lopez-Goni, I., Moreno, E., Gorvel, J.-P. (1998). Brucella abortus Transits through the Autophagic Pathway and Replicates in the Endoplasmic Reticulum of Nonprofessional Phagocytes. Infect. Immun. 66: 5711-5724 [Abstract] [Full Text]  
  • Garduno, R. A., Garduno, E., Hoffman, P. S. (1998). Surface-Associated Hsp60 Chaperonin of Legionella pneumophila Mediates Invasion in a HeLa Cell Model. Infect. Immun. 66: 4602-4610 [Abstract] [Full Text]  
  • Rittig, M. G., Schroppel, K., Seack, K.-H., Sander, U., N'Diaye, E.-N., Maridonneau-Parini, I., Solbach, W., Bogdan, C. (1998). Coiling Phagocytosis of Trypanosomatids and Fungal Cells. Infect. Immun. 66: 4331-4339 [Abstract] [Full Text]  
  • Wiater, L. A., Dunn, K., Maxfield, F. R., Shuman, H. A. (1998). Early Events in Phagosome Establishment Are Required for Intracellular Survival of Legionella pneumophila. Infect. Immun. 66: 4450-4460 [Abstract] [Full Text]  
  • Byrne, B., Swanson, M. S. (1998). Expression of Legionella pneumophila Virulence Traits in Response to Growth Conditions. Infect. Immun. 66: 3029-3034 [Abstract] [Full Text]  
  • MARUTA, K., MIYAMOTO, H., HAMADA, T., OGAWA, M., TANIGUCHI, H., YOSHIDA, S.-I. (1998). Entry and Intracellular Growth of Legionella dumoffii in Alveolar Epithelial Cells. Am. J. Respir. Crit. Care Med. 157: 1967-1974 [Abstract] [Full Text]  
  • Purcell, M., Shuman, H. A. (1998). The Legionella pneumophila icmGCDJBF Genes Are Required for Killing of Human Macrophages. Infect. Immun. 66: 2245-2255 [Abstract] [Full Text]  
  • Pizarro-Cerda, J., Moreno, E., Sanguedolce, V., Mege, J.-L., Gorvel, J.-P. (1998). Virulent Brucella abortus Prevents Lysosome Fusion and Is Distributed within Autophagosome-Like Compartments. Infect. Immun. 66: 2387-2392 [Abstract] [Full Text]  
  • Andrews, H. L., Vogel, J. P., Isberg, R. R. (1998). Identification of Linked Legionella pneumophila Genes Essential for Intracellular Growth and Evasion of the Endocytic Pathway. Infect. Immun. 66: 950-958 [Abstract] [Full Text]  
  • Sinai, A., Webster, P, Joiner, K. (1997). Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interaction. J. Cell Sci. 110: 2117-2128 [Abstract]  
  • Talloczy, Z., Jiang, W., Virgin, H. W. IV, Leib, D. A., Scheuner, D., Kaufman, R. J., Eskelinen, E.-L., Levine, B. (2002). Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc. Natl. Acad. Sci. USA 99: 190-195 [Abstract] [Full Text]  


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