About This Cover
Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): Invasin-mediated bacterial uptake. The Yersinia pseudotuberculosis surface protein invasin mediates internalization through binding to multiple β1-integrin receptors. Invasin-mediated uptake stimulates various intracellular signaling pathways, including the Rho GTPase signaling pathway. Rho GTPases RhoG and Rac1 are activated by invasin-mediated binding and are required for successful internalization. This image is a composite of 10 different nascent phagosomes during the various stages of internalization. Pink-red regions represent extracellular portions of bacteria while blue regions represent internalized portions. COS1 cells were incubated with plasmid-cured Y. pseudotuberculosis for 20 min, fixed, and processed for immunofluorescence microscopy. (See related article on p. 4771.)
[Table of Contents]
Copyright © 2009 by the American Society for Microbiology. For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»